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Quality products?make an important contribution to long-term revenue and profitability. Quality manufacturer supply Vortioxetine 508233-74-7 in stock with high standard
1.What is the Vortioxetine ?
Vortioxetine can be used in biological study of effectiveness of long term vortioxetine treatment of patients with major depressive disorder.
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![1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]-piperazine-2,6-dione](/upload/2026/9/5b6628a0c1ed4a0fb20217c7a661e8ae_1e36ad2f-24e8-4e13-ba99-ec422e83868c.png)
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1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]-piperazine-2,6-dione
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508233-74-7
vortioxetine
| Conditions | Yield |
|---|---|
|
With
triethylsilane; iodine; titanium tetrachloride;
In
dichloromethane;
at 0 - 30 ℃;
for 5.16667h;
Time;
Inert atmosphere;
|
97.6%
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 - 25 ℃;
for 3h;
under 15001.5 Torr;
Reagent/catalyst;
Temperature;
|
94%
|
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960203-28-5
Vortioxetine hydrochloride
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508233-74-7
vortioxetine
| Conditions | Yield |
|---|---|
|
With
ammonium hydroxide;
In
water;
at 20 ℃;
for 1h;
pH=8 - 9;
Concentration;
|
95.5%
|
|
With
sodium hydroxide;
at 20 ℃;
for 1h;
|
91%
|
|
With
sodium hydroxide;
In
ethyl acetate;
at 20 ℃;
for 1h;
|
1.21 g
|
|
With
sodium hydroxide;
In
dichloromethane;
at 0 - 65 ℃;
|
2.What is the CAS number for Vortioxetine ?
The CAS number of Vortioxetine is 508233-74-7.
More information of Vortioxetine 508233-74-7 are:
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CAS?Number |
508233-74-7 |
|
Density |
1.164 g/cm3 |
|
Boiling Point |
424.833 °C at 760 mmHg |
|
Flash Point |
210.732 °C |
|
HS CODE |
2933599090 |
|
PSA |
40.57000 |
|
LogP |
4.25800 |
|
Pka |
8.85±0.10(Predicted) |
3.What are another words for Vortioxetine ?
Synonyms?for?Vortioxetine 508233-74-7:1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine;Lu AA 21004;
4.What is the molecular formula of Vortioxetine?
The chemical formula of ?Vortioxetine is?C18H22N2S which containing 18 Carbon atoms,22 Hydrogen atoms,2 Nitrogen atoms and 1 Sulfur atoms,and the molecular weight of??Vortioxetine?is 298.452.
5.What is Vortioxetine (508233-74-7) used for?
In September 2013, vortioxetine (also known as Lu AA21004) was approved in the United States for the treatment of major depressive disorder (MDD). Vortioxetine was discovered from a designed multiple ligand approach to identifying an antidepressant agent that combined SERT inhibition with 5-HT1A agonism to more rapidly desensitize 5-HT1A receptors and 5-HT3A antagonism to improve mood and cognitive function. Vortioxetine has a human SERT IC50=5.4 nM, an EC50=200 nM as a human 5-HT1A receptor agonist (efficacy=96%; Ki=39 nM), and an IC50=12 nM as a human 5-HT3A receptor antagonist (Ki=3.7 nM). It has weak inhibition of the dopamine and norepinephrine transporters, but high affinity for the human β1-noradrenergic receptor (Ki=46 nM), human 5-HT1B receptor (Ki=33 nM, partial agonist), and the human 5-HT-7 receptor (Ki=19 nM, antagonist).
InChI:InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
Relevant articles related to Vortioxetine:
|
Article |
Source |
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Redox-active benzimidazolium sulfonamides as cationic thiolating reagents for reductive cross-coupling of organic halides |
Zhang, Weigang,Huang, Mengjun,Zou, Zhenlei,Wu, Zhengguang,Ni, Shengyang,Kong, Lingyu,Zheng, Youxuan,Wang, Yi,Pan, Yi , p. 2509 - 2514 (2021/03/01) |
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Regioselective C-H Thioarylation of Electron-Rich Arenes by Iron(III) Triflimide Catalysis |
Dodds, Amy C.,Sutherland, Andrew , p. 5922 - 5932 (2021/05/04) |
6.Buy Vortioxetine with the best price .
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird) is a quality supplier of Vortioxetine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Vortioxetine 508233-74-7.
