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1.What is the VARESPLADIB ?
Varespladib has been used as a secretory phospholipase A (sPLA2) inhibitor: to test its effect on the human astrocytes subjected to psychosine-induced toxicityto test its neutralization functionality on the black snake species P. colletti?venom in combination with snake venom metalloproteinases (SVMP)-inhibitor, marimastat to test its protective functionality on envenoming by vipers
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![[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid methyl ester](/upload/2026/10/2c9edc121e4e4f8a906a5c6c0e6b2ee8_3936bb9b-d232-40f5-aab2-1a1336ef1c45.png)
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172733-08-3
[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid methyl ester
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172732-68-2
((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
methanol;
for 0.666667h;
Heating;
|
74%
|
|
With
hydrogenchloride;
In
methanol; sodium hydroxide; ethyl acetate;
|
74%
|
|
With
hydrogenchloride;
In
sodium hydroxide; ethyl acetate;
|
74%
|
|
With
hydrogenchloride;
In
methanol; sodium hydroxide; ethyl acetate;
|
74%
|
|
With
hydrogenchloride;
In
methanol; ethyl acetate;
|
74%
|
|
With
hydrogenchloride;
In
methanol; sodium hydroxide; ethyl acetate;
|
74%
|
|
With
hydrogenchloride; sodium hydroxide;
In
methanol; ethyl acetate;
|
74%
|
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889675-08-5
tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate
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172732-68-2
((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid
| Conditions | Yield |
|---|---|
|
With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
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98%
|
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With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
|
2.What is the CAS number for VARESPLADIB ?
The CAS number of VARESPLADIB is 172732-68-2.
More information of VARESPLADIB 172732-68-2 are:
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CAS?Number |
172732-68-2 |
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Density |
1.32±0.1 g/cm3(Predicted) |
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Melting Point |
230-234 °C |
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Boiling Point |
667.9°C at 760 mmHg |
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Flash Point |
357.7°C |
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Vapor Pressure |
9.53E-19mmHg at 25°C |
|
PSA |
111.62000 |
|
LogP |
3.08370 |
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Pka |
3.12±0.40(Predicted) |
3.What are another words for VARESPLADIB ?
Synonyms?for?VARESPLADIB 172732-68-2:VARESPLADIB;
4.What is the molecular formula of VARESPLADIB?
The chemical formula of ?VARESPLADIB is?C21H20N2O5 which containing 21 Carbon atoms,20 Hydrogen atoms,2 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of??VARESPLADIB?is 380.398.
5.What is VARESPLADIB (172732-68-2) used for?
VARESPLADIB, also known as Varespladib methyl, is a small molecule inhibitor that targets the Phospholipase A2 (PLA2) enzyme family. It is a synthetic compound designed to modulate the activity of these enzymes, which play a crucial role in various cellular processes, including inflammation and cell membrane repair. VARESPLADIB has shown potential therapeutic applications in various diseases and conditions.
InChI:InChI=1/C21H20N2O5.Na/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13;/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25);/q;+1/p-1
Relevant articles related to VARESPLADIB:
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Article |
Source |
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The first potent inhibitor of mammalian group X secreted phospholipase A2: Elucidation of sites for enhanced binding |
Smart, Brian P.,Oslund, Rob C.,Walsh, Laura A.,Gelb, Michael H. , p. 2858 - 2860 (2007/10/03) |
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Indole sPLA2 inhibitors |
- , (2008/06/13) |
6.Buy VARESPLADIB with the best price .
NANCHANG QINZHI SCI&TEC.CO.,LTD is a quality supplier of VARESPLADIB. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on VARESPLADIB 172732-68-2.
